Sorry for the delayed response.
The LR-16 should be compatible with 10.11.
We discovered there’s some situation (usually right after to change the sample rate) depending on the user’s software enveiroment on MAC which can cause issue, but usually this can be solved by rebooting or diconnect-reconnet the LR-16 to the Computer.
We already started to investigate this issue, and we planning to relase a patch for this problem.